- This WHO-funded systematic review found that 1 in 10 recently pregnant or pregnant women who are hospitalized have COVID-19.
- This population has increased risk for ICU admission, the review authors found.
- Preterm birth risk is increased with COVID-19.
Why this matters
- Telehealth appointments may balance need for multidisciplinary antenatal care against unnecessary virus exposure.
- 77 studies; 13,118 pregnant/recently pregnant women and 83,486 nonpregnant women of reproductive age.
- Overall COVID-19 rate among pregnant/recently pregnant women:
- 10% (95% CI, 7%-14%).
- 26 studies; 11,432 women.
- Compared with nonpregnant women with COVID-19, pregnant/recently pregnant women were (ORs; 95% CIs):
- Less likely to have fever: 0.43 (0.22-0.85);
- Less likely to have myalgia: 0.48 (0.45-0.51);
- More likely to be admitted to ICU: 1.62 (1.33-1.96);
- More likely to need invasive ventilation: 1.88 (1.36-2.60).
- Risk factors (ORs; 95% CIs) for severe COVID-19 in pregnancy:
- Increased age (≥35 years): 1.78 (1.25-2.55);
- High BMI (≥30 kg/m2): 2.38 (1.67-3.39);
- Chronic hypertension: 2.0 (1.14-3.48);
- Preexisting diabetes: 2.51 (1.31-4.80).
- Preexisting comorbidities among pregnant women with COVID-19 were associated (ORs; 95% CIs) with:
- ICU admission: 4.21 (1.06-16.72);
- Invasive ventilation: 4.48 (1.40-14.37).
- COVID-19 in pregnancy was associated (ORs; 95% CIs) with:
- Preterm birth: 3.0 (1.15-7.85);
- Neonatal ICU admission: 3.13 (2.05-4.78).
- Heterogeneity among studies was low or nil.
- Living systematic metareview.
- Funding: WHO.
- Limited generalizability.
- Small sample sizes.
- Possible duplicate data.
- Paucity of comparative data.