COVID-19: DVT was common among inpatients in Wuhan

  • Zhang L & al.
  • Circulation
  • 18 May 2020

  • curated by Jenny Blair, MD
  • Clinical Essentials
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • Among inpatients with COVID-19 in Wuhan, China, deep venous thrombosis (DVT) was common, according to results of this single-center study.

Why this matters

Key results

  • 37.1% received low-molecular-weight heparin thromboprophylaxis (similar rates in those with vs without DVT).
  • 74.1% were severely or critically ill.
  • DVT prevalence: 46.1% (66/143 patients). 
  • Among subgroup with Padua score ≥4 who underwent ultrasound >72 hours after admission:
    • Heparin nonprophylaxis vs prophylaxis: 66.0% vs 36.7% (P=.010).
  • DVT vs no DVT:
    • ICU admission: 12 vs 3 (P=.005).
    • Discharges: 32 vs 60 (P<.001>
    • Deaths: 23 vs 9 (P=.001).
  • Risk factors (ORs; 95% CIs) for DVT on multivariate analysis:

Study design

  • Single-center observational study of 159 consecutive patients hospitalized with COVID-19 in Wuhan, China (n=143).
  • All underwent leg ultrasound, echocardiography, except 16 who died or were transferred.
  • Outcomes: DVT prevalence, risk factors, prognosis.
  • Funding: National Natural Science Foundation of China.

Limitations

  • Patients had waited a long time for admission because of crowding.
  • Scant data on thromboprophylaxis. 
  • Pulmonary embolism prevalence not determined.
  • No control group.