- Chinese COVID-19 cohort data highlight rapid virus spread, highly variable clinical presentation.
- ECDC reports that COVID-19 continues to spread through the EU/EEA and UK and risk is currently "moderate to high."
Why this matters
- Compromised respiratory status on admission is the primary driver of disease severity.
- Early diagnosis, isolation, symptomatic care provision essential.
- Ensure familiarity with ECDC contact tracing and surveillance.
- 1099 patients.
- 43.9% Wuhan residents, 72.3% had contact with Wuhan residents; 1.9% had wildlife contact.
- Median incubation: 4 (interquartile range [IQR], 2-7) days.
- Median age: 47 (IQR, 35-58) years; 41.9% female.
- Symptoms: fever (43.8%), cough (67.8%); nausea/vomiting (5.0%), diarrhea (3.8%).
- Comorbidity: 23.7%.
- 86.2% (840/975) had abnormal CT; most commonly ground-glass opacity (56.4%), bilateral patchy shadowing (51.8%).
- 17.9% (157/877), 2.9% (5/173) patients with nonsevere, severe disease, respectively, had no CT abnormalities.
- 6.1% met primary composite endpoint: 5.0% ICU admission, 2.3% mechanical ventilation, 1.4% died.
- Cumulative endpoint risk: 3.6%, 20.6%, mild, severe cases, respectively.
- Retrospective cohort analysis of Wuhan patients with confirmed COVID-19 requiring ICU admission, mechanical ventilation, or who had died through 20 January, 2020.
- Funding: National Health Commission of China, others.
- Variable, incomplete documentation.
- Recall, selection bias.
- Censored clinical outcomes.