- French clinicians highlight neurological symptoms such as drowsiness and hypotonia in infants (ages
- Cerebrospinal fluid (CSF) samples from all patients were SARS-CoV-2-negative.
- UK and Italian researchers have reported case series of Kawasaki-like, severe multisystem inflammatory COVID-19 manifestations in children.
Why this matters
- With limited information available on COVID-19 presentation in infants, clinical suspicion is warranted.
- Infants with isolated fever should be tested for SARS-CoV-2 infection.
- Close monitoring for 2 weeks can be warranted.
- 5 male infants, average age 2 months, admitted with poorly tolerated fever (37.4-38.5°C); all had SARS-CoV-2-positive nasopharyngeal swabs.
- Oxygen saturation was normal in all cases.
- 4/5 had rhinitis; 4/5 had coughs; 4/5 had mottled skin.
- 4/5 showed neurological symptoms at admission: axial hypotonia, drowsiness, moaning.
- None had received NSAIDs before admission.
- During hospitalization, infants received only acetaminophen.
- Fever peak during hospitalization: 38-39°C.
- Cerebrospinal fluid was clear, RT-PCR negative for SARS-CoV-2.
- Chest X-rays showed no relevant abnormalities.
- Clinical course was rapidly favorable.
- 1 infant had transient diffuse erythema, mild diarrhea.
- Overall hospital stay was 1-3 days.
- All were followed by daily phone check-ins for 2 weeks.
- Parents of these infants had signs for