The findings of a new study suggest a higher risk of venous thromboembolism (VTE) in women diagnosed with COVID-19 in the setting of childbirth.
The study, published in JAMA Internal Medicine, examined outcomes among 406,446 women hospitalised for childbirth between April 1 and November 23, 2020.
Of 6,380 women with COVID-19 who gave birth, 98.9 per cent were discharged home, 212 (3.3%) needed intensive care, 86 (1.3%) needed mechanical ventilation, and nine (0.1%) died in hospital.
In-hospital mortality was significantly higher in women with vs without COVID-19 (141; 95% CI 65-268 vs 5.0; 95% CI 3.1-7.7 deaths per 100,000 women). Rates of myocardial infarction (MI) and VTE were higher in the women with vs without COVID-19 (MI: 0.1% vs 0.004%; VTE: 0.2% vs 0.1%; P<.001>
COVID-19 was associated with higher odds of preeclampsia (adjusted odds ratio [aOR] 1.21; 95% CI 1.11-1.33) and preterm birth (aOR 1.17; 95% CI 1.06-1.29) but was associated with significantly higher odds of stillbirth (aOR 1.23; 95% CI, 0.87-1.75).
The authors say the findings highlight the need for strategies to minimise risk and also underscore the importance of including this population in clinical trials of treatments and vaccines.