- SARS-CoV-2 viral clearance appears to be influenced by male sex, disease severity, and lymphopenia.
- Prolonged clearance time is also influenced by fecal viral RNA positivity.
Why this matters
- High-dose corticosteroids do not appear to be more effective than moderate- to low-dose corticosteroids.
- Longer isolated observation might be warranted in patients with positive fecal viral RNA.
- 99 patients (61.6% male).
- 61.6% (n=61) tested virus-negative and 38.4% (n=38) tested virus-positive after several days.
- Median age: 54 years, with 22.2% aged >65 years.
- Median time of persistent viral shedding: 16 (interquartile range, 13-21) days.
- 19 days for virus positive vs 15 days for virus negative (P=.002).
- Factors independently associated (HRs; 95% CIs) with longer SARS-CoV-2 RNA shedding on multivariate analysis:
- Male sex: 0.58 (0.35-0.98).
- Immunoglobulin use: 0.42 (0.24-0.76).
- APACHE II score: 0.89 (0.84-0.96).
- Lymphocyte count: 1.81 (1.05-3.10).
- Patients with positive fecal samples took longer than those with negative fecal samples to clear the virus (log-rank, P=.003).
- Single-center, retrospective cohort analysis characterizing factors influencing duration of SARS-CoV-2 shedding in patients with negative vs persistent positive virus detection during hospitalization.
- Funding: Zhejiang Provincial Natural Science Foundation of China.
- 28-day cutoff point.
- Limited generalizability.