- Patients with Crohn’s disease, especially younger adults, were likelier than their matched counterparts without IBD to develop diabetes mellitus (DM) in this population-based study.
- Authors suggest monitoring these patients for diabetes.
Why this matters
- Steroid use among patients with IBD may result in insulin resistance and hyperglycemia, but a causal link between IBD and diabetes is debated.
- Mean follow-up, 5.1 years.
- Diabetes incidence (HRs; 95% CIs):
- IBD vs controls, fully adjusted HR: 1.135 (1.048-1.228; P=.0018).
- Crohn’s vs controls, fully adjusted HR: 1.677 (1.408-1.997; P<.0001 class="">
- Ulcerative colitis vs controls, fully adjusted: nonsignificant difference.
- IBD vs controls, aged 20 years: HR, 2.001 (95% CI, 1.226-3.265; P=.0055).
- IBD vs controls, aged 30 years: 1.608 (1.245-2.077; P=.0003).
- IBD vs controls, aged ≥40 years: nonsignificant difference.
- Retrospective nationwide population-based cohort study using South Korea’s National Health Insurance database (n=48,420).
- Authors matched 8070 patients with IBD to 40,350 control patients and followed them over time.
- Covariates: age, sex, BMI, exercise, smoking, drinking, baseline blood glucose, steroid use.
- Outcome: new-onset DM.
- Funding: None disclosed.
- Causation not established.
- Types 1 and 2 diabetes not distinguished.
- No data on IBD severity.
- Unclear if age-related subgroup analyses were adjusted.