- In patients with Crohn's disease, there is no added benefit of an amino acid-rich elemental diet (ED) with concomitant anti-TNF therapy compared with anti-TNF therapy alone.
Why this matters
- ED may not be an effective treatment option for patients receiving maintenance anti-TNF therapy.
- Multicenter, prospective cohort study of 72 patients with Crohn’s disease who had positive clinical response to maintenance infliximab or adalimumab (a change in the Crohn’s Disease Activity Index of >70 and
- Assignment to the ED group (Elental) was based on patient preference and positive tolerability test of ED at 900 kcal/day for 3 days.
- ED plus anti-TNF therapy (n=37) was compared with anti-TNF therapy without ED (n=35).
- The primary outcome was cumulative remission rate at 2 years after baseline.
- Funding: EA Pharma Co., Ltd.
- No significant difference between groups in cumulative remission rate at 2 years (60.9% of ED group vs 56.7% of the anti-TNF alone group; P=.98).
- Adherence to ED was low, with only 29.7% of the ED group consuming ≥900 kcal/day.
- Nonrandomized design.
- Bias in allocation to the ED group.