- More than 1 cup of coffee/day (vs ≤1 cup/day) is tied to reduced risk for breast cancer in postmenopausal but not premenopausal women, according to results of the Spanish SUN prospective cohort study.
Why this matters
- Results should be reassuring to coffee drinkers, but warrant replication in a controlled trial.
- Prospective cohort study (N=10,812) of women without breast cancer at entry.
- Coffee consumption was assessed by the 136-item food-frequency questionnaire.
- The breast cancer diagnosis was self-reported, but had to be confirmed by medical record review.
- Funding: Spanish Government-Instituto de Salud Carlos III; others.
- Follow-up: 115,802 person-years and a median of 11.8 years.
- >1 cup/day (vs ≤1 cup/day) was associated with a 56% decreased risk for breast cancer in postmenopausal women: adjusted HR, 0.44 (95% CI, 0.21-0.92; adjusted for family history of breast cancer, smoking status, smoking pack years, physical activity, alcohol intake, etc.).
- >1 cup/day (vs ≤1 cup/day) was not associated with a decreased risk for breast cancer in premenopausal women: adjusted HR, 1.69 (95% CI, 0.96-2.96).
- Observational design.