- Among patients with de novo follicular lymphoma (FL) treated with first-line chemoimmunotherapy, those with histological grade 3A disease (G3A FL) have long-term outcomes comparable to those with grades 1-2 disease (G1-2FL).
Why this matters
- Compared with other histological grades in FL, less is known regarding the effect of grade 3 histology, particularly in the rituximab era.
- Study to investigate the effect of histological grades in 250 patients with FL treated with first-line chemoimmunotherapy.
- 188 patients had G1-2FL; 62 had G3A FL.
- Funding: Instituto de Salud Carlos III.
- In patients with G3A FL vs G1-2FL:
- Estimated 6-year PFS: 56% (95% CI, 39%-73%) vs 55% (95% CI, 46%-63%; P=.782).
- 6-year time to progression: 51% (95% CI, 41-61%) vs 57% (95% CI, 49-65%; P=.521).
- Estimated 6-year OS probability: 76% (95% CI, 64%-88%) vs 83% (95% CI, 77%-89%; P=.044).
- Cumulative incidence curves of death not related to lymphoma at 10 years: 0.26 (95% CI, 0.25-0.27) vs 0.05 (95% CI, 0.04-0.06).
- No relapses were seen after 6 years in patients with G3A FL.
- Data for key molecular features not available.