Dementia, cognitive decline predicted by ideal cardiovascular health index
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Ideal cardiovascular health (CVH) index predicts risk for dementia and cognitive decline as well as risk for cerebrovascular disease.
2750 Framingham Heart Study Offspring cohort participants (mean age, 62±9 y; 45% men), free of stroke and dementia at baseline, underwent measurement of 10-y risks of incident stroke and dementia, and ≈7 y risks of cognitive decline and MRI brain atrophy.
Ideal CVH determination was 0-7-points (1 point each for nonsmoking, ideal body mass index, regular physical activity, healthy diet, optimum blood pressure, cholesterol, and fasting glucose).
Recent ideal CVH was associated with lower risk of vascular dementia (HR, 0.49; 95% CI, 0.30-0.81), frontal brain atrophy (P=.003), decline ...