- Head injury is associated with an increased relative risk (RR) in dementia and Alzheimer's disease (AD).
Why this matters
- Clinicians should consider the potential for the development of dementia when assessing head injuries.
- Researchers included data from 32 studies (total n=2,013,197).
- Head injury significantly increased the RR for dementia (RR, 1.63) and AD (RR, 1.51). However, both results showed significant heterogeneity between studies.
- Head injury with loss of consciousness did not show significant increases in relative risk for either dementia or AD.
- Researchers detected no significant publication bias.
- Systematic review and meta-analysis of cohort and case-control studies examining the relationship between head injury and AD.
- Funding: Jiamusi University.
- Many studies included relied on self-report.
- Severity of head injury was not available for all patients.