Dementia: switching acetylcholinesterase inhibitor medication leads to benefits

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Takeaway

  • Switching acetylcholinesterase inhibitor (ChEI) medication may lead to cognitive or affective benefits in some patients.

Why this matters

  • For patients who are underserved by ChEI medication, a switch may be in order.

Key results

  • 6 mo after the switch, patients with Alzheimer's disease (AD) were taking lower doses of the new ChEI medication compared with the dose they were taking before (P=.000).
  • Patients who switched from galantamine to donepezil saw cognitive benefits after the switch, but not those who switched to rivastigmine.
  • Patients who ...