- Switching acetylcholinesterase inhibitor (ChEI) medication may lead to cognitive or affective benefits in some patients.
Why this matters
- For patients who are underserved by ChEI medication, a switch may be in order.
- 6 mo after the switch, patients with Alzheimer's disease (AD) were taking lower doses of the new ChEI medication compared with the dose they were taking before (P=.000).
- Patients who switched from galantamine to donepezil saw cognitive benefits after the switch, but not those who switched to rivastigmine.
- Patients who switched from rivastigmine to galantamine saw affective benefits, but not those who switched to donepezil.
- Retrospective study of 171 patients with AD who changed ChEI medication.
- Funding: Ministry of Education, Science, Culture, and Sports of Japan.
- Small sample size.
- Retrospective study design.