- A study of patients with major depressive disorder who had achieved remission or partial remission with antidepressant treatment shows a high frequency of persistent symptoms, including sleep problems, fatigue, impaired concentration, and appetite/weight disturbances.
- Just 10.0% of remitted patients were completely free of mood symptoms, as measured by the Quick Inventory of Depressive Symptomatology-Self Report (QIDS-SR).
Why this matters
- Residual mood and somatic symptoms during remission have been studied previously, but most studies were secondary analyses of clinical trials that had strict entry criteria.
- The current study focused on a broad patient population.
- 1503 participants evaluated who responded to antidepressant treatment and reported ≥50% improvement in depressive symptom on the visual analog scale.
- Funding: The Beijing Municipal Administration of Hospitals Incubating Program; others.
- 770 remitters (QIDS-SR ≤5) and 733 nonremitters (QIDS-SR>5).
- Of the depression domains measured using QIDS-SR, most frequent residual symptoms included:
- Sleep disturbances (24.9%);
- Appetite/weight disturbances (3.8%);
- Loss of interest (0.9%);
- Fatigue (0.8%);
- Decreased concentration (0.6%).
- Of the 770 remitters, 10% were free of residual mood symptoms (QIDS-SR total score, 0).
- Overall, 4.8% participants were free of both residual mood and somatic symptoms.
- Limited generalizability.