- Migraine-related disability is significantly more common among patients who also have a history of depression, anxiety, or both.
- Depression affects almost one-third of patients with migraine, and anxiety affects almost a quarter.
- Both conditions are more common among patients with chronic migraine.
Why this matters
- Interventions targeting psychiatric comorbidities may reduce disability among patients with migraine.
- Subanalysis of the longitudinal, Internet-based Chronic Migraine Epidemiology and Outcomes Study.
- 16,788 patients with a history of migraine.
- Funding: Allergan, pre-AbbVie.
- 91.2% had episodic migraine and 8.8% had chronic migraine.
- 32.3% of participants had depression and 29.9% had anxiety.
- 9.6% of participants had depression only, 7.2% anxiety only, 22.7% both depression and anxiety, and 60.5% neither.
- Patients with chronic migraine were significantly more likely to have depression (56.6% vs 30.0%; P<.001 and anxiety vs p than those with episodic migraine.>
- Patients with episodic migraine were more likely to have neither depression nor anxiety (62.7% vs 36.9%; P<.001>
- After multivariable analysis, risk (rate ratios) of migraine-related disability was significantly higher in those with:
- Depression alone: 1.56 (P<.001>
- Anxiety alone: 1.39 (P<.001>
- Depression and anxiety together: 1.79 (P<.001>
- Participants were mostly women (74.4%) and White (84.0%).