Depression in type 1 diabetes patients may up dementia risk

  • Gilsanz P & al.
  • Aging Ment Health
  • 10 Apr 2018

  • from Sarfaroj Khan
  • Clinical Summaries
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Takeaway

  • Depression in patients with type 1 diabetes mellitus (T1D) is associated with significantly increased risk for dementia
  • This risk was found to be independent of vascular comorbidities and proximal glycaemic control.

Why this matters

  • Depression is commonly associated with worse self-care, poorer adherence and increased risk for complications.
  • Depression in patients with T1D is commonly diagnosed during mid-adulthood or earlier, which makes it necessary to understand the possible negative brain health effect of T1D among this population.

Study design

  • This study assessed 3742 participants with T1D (no depression, n=2990; depression, n=752) and were followed for dementia onset from 1996 to 2015.
  • Dementia diagnoses were identified using the International Statistical Classification of Diseases, ninth edition.
  • Funding: National Institute on Aging.

Key results

  • Mean age of the participants was 56.1 years.
  • 20% had baseline depression and 5% of the participants developed dementia during follow-up.
  • After adjustments, risk for dementia was 72% higher in participants with depression (aHR, 1.72; 95% CI, 1.12-2.65).
  • Baseline depression was found to be associated with 126% increased risk for dementia after 5 years (HR, 2.26; 95% CI, 1.24-4.11).

Limitations

  • Brain imaging was not available.
  • Age of diabetes onset was unknown.