- Dialysis patients with depression have a significantly higher risk for mortality and severe and fatal infections compared with patients without depression.
Why this matters
- The findings point to the need for including mental healthcare as part of the regular medical care of patients undergoing dialysis.
- The study evaluated 56,414 patients (age, ≥18 years) who initiated ≥90 days of chronic dialysis from the National Health Insurance Research Database of Taiwan during 2000-2007.
- Outcomes: all-cause mortality, major adverse cardiovascular events (MACE), and severe infections.
- Funding: Kaohsiung Medical University Hospital.
- Mean follow-up time was 3.2 years.
- Patients with depression had a significantly higher risk for mortality vs those without (45.29% vs 39.52%; aHR, 1.24; P<.001>
- Patients with depression showed significant association with (all P<.001 style="list-style-type:circle;">
- severe infections (aHR, 1.14),
- fatal infections (aHR, 1.22),
- sepsis (aHR, 1.19),
- septic shock (aHR, 1.36), and
- pneumonia (aHR, 1.19).
- Observational design.
Coauthored with Antara Ghosh, PhD