- Late-life depression was associated with a higher risks for early all-cause and cardiovascular mortality among community-dwelling elders.
Why this matters
- Late-life depression, which is largely untreated, is associated with a higher prevalence of somatic depressive symptoms compared with depression in younger adults.
- Meta-analysis of 61 prospective cohort studies involving 198,589 older adults (aged 60-85 years) identified after a search on PubMed, EMBASE, Web of Science, and PsycINFO between January 1966 and February 2018.
- Funding: None disclosed.
- Risk for all-cause mortality was significantly higher in older adults with depression (risk ratio [RR], 1.34; 95% CI, 1.27-1.42; I2=54.4%) vs those without.
- Risk for cardiovascular mortality was higher in older adults with depression (RR, 1.31; 95% CI, 1.20-1.43; I2=75.9%) vs those without.
- The association remained significant after excluding cohorts that appeared asymmetric in a funnel plot: all-cause mortality (RR, 1.22; 95% CI, 1.15-1.30) and cardiovascular mortality (RR, 1.11; 95% CI, 1.01-1.22).
- Heterogeneity across studies.
Coauthored with Antara Ghosh, PhD