Depression tied to poor survival in blood cancers

  • Hasegawa T & al.
  • Psychooncology
  • 2 Jul 2019

  • curated by David Reilly
  • Univadis Clinical Summaries
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • Patients with hematological malignancies and depression at baseline demonstrated inferior survival, regardless of whether they remained depressed or recovered from depression.

Why this matters

  • 12%-33% of patients with hematological malignancies demonstrate symptoms of depression.

Study design

  • Study to investigate depressive symptoms in 255 patients with newly diagnosed malignant lymphoma (n=184) or multiple myeloma (n=71) before chemotherapy (T1) and 1 month later (T2) using the Patient Health Questionnaire-9 (PHQ-9).
  • Patients with depressive symptoms were subdivided as follows:
    • New depressive symptoms at T2 (new onset; n=19).
    • Remission of depressive symptoms at T2 (remission; n=38).
    • Persistent depressive symptoms from T1 to T2 (persistent; n=26).
  • Funding: Japanese Society for the Promotion of Science; others.

Key results

  • Inferior OS in patients with vs without depression (aHR, 2.43; 95% CI, 1.43-4.12; P<.001>
  • Adjusted HRs for OS (never-depressed as reference group):
    • New onset: aHR, 1.91; 95% CI, 0.77-4.75; P=.166.
    • Remission: aHR, 2.98; 95% CI, 1.55-5.74; P=.001.
    • Persistent: aHR, 2.17; 95% CI, 1.01-4.68; P=.047.
  • Shorter OS in depressed vs never-depressed patients by malignancy:
    • Malignant lymphoma: aHR, 2.72; 95% CI, 1.30-5.71; log-rank P=.004.
    • Multiple myeloma: aHR, 2.39; 95% CI, 0.94-6.08; log-rank P=.050.

Limitations

  • Patient-reported data via questionnaires; no interview-based assessments.

Please confirm your acceptance

To gain full access to GPnotebook please confirm:

By submitting here you confirm that you have accepted Terms of Use and Privacy Policy of GPnotebook.

Submit