- In elderly patients with diabetes, overweight status, poor physical capabilities and low activity level and the presence of >2 additional illnesses were the risk factors for depression.
- Metformin was found to be protective against depression in elderly patients with diabetes.
Why this matters
- Few studies have focused on the risk factors for depression in elderly patients with diabetes and not much is known regarding the effect of metformin on elderly patients with depression.
- This case-control study included 110 elderly patients with diabetes having depression (cases) and gender- and age-matched 440 non-depressed control patients.
- Funding: Liaoning Department of Education and others.
- Risk factors for depression in elderly patients with diabetes included (all P<.05 style="list-style-type:circle;">
- overweight status (adjusted OR [aOR], 2.031; 95% CI, 1.180-3.495);
- poor physical capabilities and low activity level (aOR, 2.342; 95% CI, 1.465-3.743); and
- presence of >2 additional illnesses (aOR, 5.350; 95% CI, 2.222-12.883).
- Self-reported data.
- Newly diagnosed participants were not included.