- For detecting dysplasia in IBD, chromoendoscopy (CE) bests white light endoscopy (WLE) for detecting nonpolypoid lesions.
- This meta-analysis also shows CE superiority over high-definition (HD) WLE.
Why this matters
- Recent findings have been mixed, some leaning toward CE as a replacement for WLE but others pointing to no increased detection with CE.
- CE bested WLE for (risk ratios, 95% CIs):
- Dysplasia detection: 2.05 (1.62-2.61; P<.00001 limited heterogeneity>).
- Dysplastic lesion detection: 2.04 (1.40-2.98; P=.0002; significant heterogeneity).
- Nonpolypoid dysplastic lesion detection: 1.38 (1.02-1.88; P=.04; limited heterogeneity).
- CE also bested HD-WLE in dysplasia detection, but did not beat WLE for polypoid lesion identification (0.74; 0.53-1.05; P=.09).
- Meta-analysis, 6 randomized controlled trials (n=911), 5 prospective studies (n=1327).
- Funding: Natural Science Foundation of China.
- Not all studies compared CE and WLE on the same lesions.
- Multiple endoscopists with variable experience involved in some studies.