Takeaway
- Data over the course of 15 years from Scotland suggest a significant increase in proportion of women who had pre-gestational type 1 (T1DM) and type 2 diabetes mellitus (T2DM).
- Although these mothers received increased interventions, babies were still born heavier vs those born to mothers without diabetes.
- Stillbirth and perinatal mortality remained unchanged and were higher in T1DM and T2DM vs no diabetes.
Why this matters
- Approaches used to address perinatal outcomes in women with diabetes during pregnancy need to be improved significantly.
Study design
- Study evaluated 813,921 deliveries recorded in Scotland between April 1998 and March 2013.
- Funding: Chief Scientists Office of the Scottish Government.
Key results
- Proportion of women whose pregnancies were complicated by diabetes increased significantly by 44% and 90% for T1DM and T2DM, respectively (P<.001).
- Proportion of preterm delivery increased markedly in women with T1DM (35.3%) and T2DM (21.8%) vs women without diabetes (6.1%) (P<.001), and this increased with time for both groups (P<.005).
- Despite earlier delivery, babies born to mothers with T1DM and T2DM were 68.7 g and 76 g heavier vs those born to non-diabetic mothers, but only formally statistically significant for T2DM (P<.001).
- Rates of stillbirth did not fall significantly over time for T1DM and T2DM, which were 4.0-fold and 5.1-fold of that in non-diabetic population, respectively (P<.001).
Limitations
- Detailed information on congenital anomalies and neonatal intensive care admissions not available.
References
References
