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Diabetes risk higher with psoriatic arthritis than psoriasis alone

The development of type 2 diabetes (T2D) is significantly higher in patients with psoriatic arthritis (PsA) compared with those with psoriasis alone, but the risk for cardiovascular disease in both conditions is similar. That is the conclusion of a study published in the journal Rheumatology.

The population-based study identified 6783 incident cases of PsA from the UK Clinical Practice Research Datalink between 1998 and 2014, who were matched (1:4) to a general population cohort (n=27,132) and a psoriasis cohort (n=27,132).

The data revealed a significantly increased risk for T2D in the PsA cohort compared to the general population (adjusted relative risk [RR], 1.40; 95% CI, 1.15-1.70) and the psoriasis cohort (RR, 1.53; 95% CI, 1.19-1.97), respectively.

The incidence of ischaemic heart disease (IHD) and peripheral vascular disease (PVD) was significantly higher in the PsA group than in the general population, as was the combination of cerebrovascular disease, IHD and PVD. No significant difference in risk was observed between the PsA and psoriasis cohorts for any cardiovascular outcome and the median age at incident outcomes was similar for all 3 cohorts.

Commenting on the findings, the study authors said: “These results support the proposal in existing clinical guidelines that in order to reduce cardiovascular risk in patients with PsA, it is important to treat inflammatory disease as well as to screen and treat traditional risk factors early in the disease course.”


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