- Older adults with higher dietary intakes of flavonols had lower risk for Alzheimer’s dementia in this prospective cohort study.
- Reduction seen even after adjustment for age, sex, education, APOE ɛ4 status, and participation in cognitive and physical activities.
Why this matters
- Options for preventing and treating Alzheimer’s dementia are limited.
- During median 6.1-year follow-up, 23.9% participants received an Alzheimer’s dementia diagnosis.
- Dietary flavonol intake was inversely associated with adjusted risk in Cox proportional hazards models.
- Highest vs lowest quintile of intake (HRs):
- Total flavonols: 0.52 (P=.006);
- Kaempferol: 0.50 (P=.002);
- Myricetin: 0.62 (P=.03); and
- Isorhamnetin: 0.62 (P=.02).
- Only a trend seen for quercetin intake (HR, 0.70; P=.06).
- Total flavonol intake: 5.3 mg/day in lowest quintile, 15.3 mg/day in highest.
- Community-based prospective cohort study of 921 dementia-free older adults (mean age, 81.2 years) in the Rush Memory and Aging Project.
- Diet assessed with food frequency questionnaire at annual evaluations.
- Main outcome: clinician-diagnosed Alzheimer’s dementia.
- Funding: NIH; National Institute on Aging; USDA Agricultural Research Service.
- Residual and unmeasured confounding.
- Recall and self-reporting bias for diet.
- Uncertain generalizability to nonwhite, low-education, nonvolunteer populations.
- Possibility that subclinical Alzheimer’s dementia led to altering diet.