- Transcranial direct current stimulation (tDCS) offered no significant decrease in number of headache days per month in patients with chronic migraine (CM) with medication overuse (MO).
Why this matters
- Prior studies suggested that techniques such as tDCS that modulate pain-related neural networks might be effective against chronic migraine, but study protocols were poorly designed.
- Placebo-controlled, double-blind, randomized controlled trial.
- 135 patients with CM and MO who experienced no improvement with ≥2 prior preventive therapies underwent standardized drug withdrawal protocol and anodal tDCS (n=44), cathodal tDCS (n=45), or sham tDCS (n=46).
- Funding: None.
- At 12 months, no significant difference was detected among groups in percentage of patients with a reduction of ≥50% of migraine days/month (64.1% with anodal vs 60.0% with cathodal vs 46.3% with sham).
- No significant difference was seen among groups in reduction of number of analgesics/month at 6 or 12 months.
- No adverse events in either treatment group.
- Single-center study.