- In patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL), hypercalcemia with low parathyroid hormone (PTH) level was linked to inferior survival.
Why this matters
- Hypercalcemia has been associated with poor prognosis in patients with cancer and can be primary hyperparathyroidism-related (PHPT) or lymphoma-related.
- Study to investigate prevalence of hypercalcemia in patients with newly diagnosed DLBCL and to compare clinical characteristics and outcomes in patients with vs without lymphoma-associated hypercalcemia.
- Funding: None disclosed.
- Data were sourced for 250 patients treated at 2 academic medical centers, among whom 46 (18%) presented with hypercalcemia; these were matched with 46 age- and sex-matched DLBCL control patients with normal calcium levels from a centralized database.
- Among patients with hypercalcemia vs control patients:
- Higher percentage of patients with Ann Arbor stage III-IV (P=.03).
- Higher lactate dehydrogenase levels (LDH; P<.001>
- Higher albumin levels (P<.0001>
- Response and survival outcomes were comparable.
- More advanced stage disease (P=.004).
- Higher LDH levels (P=.001).
- Lower albumin levels (P=.004).
- Significantly inferior OS (P=.016).
- Significantly inferior PFS (P=.016).
- Retrospective data.