- Tomato or lycopene intake is tied to reduced total and all-cause mortality and improved cardiometabolic risk factors.
- Tomatoes are linked to reductions specifically in coronary heart disease (CHD) and stroke mortality.
Why this matters
- These authors say data were lacking on links between tomato/lycopene intake and mortality.
- However, findings have demonstrated benefits for lipid profiles, BP, and cardiovascular disease.
- Highest tomato intake vs lowest was linked to reductions (risk ratios, fully adjusted model) in:
- Total mortality: 0.86;
- Cerebrovascular mortality: 0.70; and
- CHD mortality: 0.76 (all P<.001>
- Lycopene intake showed quite similar benefits.
- High levels of C-reactive protein attenuated the lycopene effects.
- Systolic BP, high-density lipoprotein cholesterol, and other metabolic and inflammatory markers also improved with increased tomato or lycopene intake (P<.001>
- No effect seen on BMI, diastolic BP, triglycerides.
- Obesity did not change associations.
- Data from the National Health and Nutrition Examination Surveys (1999-2010) for 23,935 participants (mean age, 47.6 years; 48.8% men), with 76.4 months of follow-up.
- High tomato intake was considered to be 1.8 cups/day; lowest intake was 0.02 cups/day.
- Lycopene intake ranged from 265 to 12,463 μg/day.
- Funding: None disclosed.
- Self-reported intake.
- Residual confounding possible.
- Causality not established.