- Autoimmune antibodies are high in women undergoing in vitro fertilization (IVF).
Why this matters
- Maternal immunity affects pregnancy success and outcomes, including infertility, preeclampsia, placental abruption, late premature birth, and unexplained IVF failure.
- These authors recommend evaluating autoimmune antibodies in all women undergoing IVF.
- Authors conclude that systemic autoimmune disease is responsible for obstetric complications in their population.
- 19.23% of women undergoing IVF had a high prevalence of persistently positive serum autoantibodies.
- Antiphospholipid antibodies were most common (8.27%) autoantibodies. These included:
- lupus anticoagulant: 53.49%;
- anticardiolipin: 44.19%; and
- anti-β2 glycoprotein 1: 25.58%.
- 6.73% fulfilled criteria for a systemic autoimmune disease.
- Observational retrospective study.
- Women who underwent IVF between 2012 and 2017 were identified (n=520).
- Clinical records from 100 consecutive patients showing positive autoantibodies evaluated.
- Funding: None.
- 1 institution; results may not be generalizable.
- Treatment success not addressed.