Does BMI influence the choice of lipid-lowering therapy?

  • Ferrières J & al.
  • Diabetes Obes Metab
  • 11 Jun 2018

  • curated by Sarfaroj Khan
  • UK Clinical Digest
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.


  • Study suggests that physicians’ decisions are directly influenced by patients’ BMI when choosing statin dose.
  • Patients with high BMI receive high dose of statin treatment even after correcting for potential confounding factors such as diabetes or a history of ischaemic heart disease.
  • Study proposes the use of established risk scores to guide clinical decision making lipid-lowering therapy.

Why this matters

  • Current guidelines recommend lowering low-density lipoprotein cholesterol (LDL-C) as the main focus for treatment of dyslipidaemia.
  • Statins form the backbone of lipid-lowering treatment; however, there is no clarity on the factors influencing their prescription in clinical practice.

Study design

  • Cross-sectional, observational study of 52,916 patients with dyslipidaemia undergoing statin treatment from the Dyslipidaemia International Study (DYSIS).
  • Funding: None disclosed.

Key results

  • Overall, 1.1% of the patients were underweight (BMI, 2), 33.1% had normal weight (18.5-24.9 kg/m2), 41.5% were overweight (25-29.9 kg/m2), 17.1% had class I obesity (30.0-34.9 kg/m2), 5.0% had class II obesity (35-39.9 kg/m2) and 2.1% had class III obesity (≥40 kg/m2).
  • BMI showed a negative correlation with high-density lipoprotein cholesterol, positive correlation with triglycerides (P<.0001 for both and no correlation with ldl-c>
  • Statin dosage showed a positive correlation with BMI (P=.001) and remained significant even after adjustments (OR, 2.4; 95% CI, 2.0-3.0).


  • Observational study.

Please confirm your acceptance

To gain full access to GPnotebook please confirm:

By submitting here you confirm that you have accepted Terms of Use and Privacy Policy of GPnotebook.