- Chronic cannabis use is associated with lower fasting insulin and lower homeostasis model assessment of insulin resistance (HOMA-IR) in adults with obesity, but not in adults without it, even at
- Lower insulin levels persist even after stopping heavy use.
Why this matters
- Data conflict regarding link between long-term cannabis use and glucose metabolic dysfunction.
- Data from National Health and Nutrition Examination Survey (2009-2016) for 129,509 adults ages 18-59 years without diabetes and not taking glucose-lowering medications.
- Funding: None disclosed.
- Median plasma fasting insulin levels:
- 9.83 µU/mL in never-users of cannabis vs 7.70 µU/mL in current users.
- No association with BMI 2, except among former users of
- Mean fasting insulin with BMI 25-30 kg/m2 among current users with
- With BMI ≥30 kg/m2, mean fasting insulin for those using
- Former frequent users had significantly lower insulin levels compared with never-users, independent of duration since last use.
- Cross-sectional design.
- Self-reported cannabis use.