- In patients with type 2 diabetes (T2D) and distal symmetric diabetic polyneuropathy (DPN), low total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels are associated with more nerve lesions, impaired nerve conduction, and greater symptom severity.
Why this matters
- DPN is a severe diabetes complication.
- Cholesterol-lowering is recommended in T2D management.
- Single-center, prospective cohort study of 100 participants with T2D (64 with DPN, 36 without).
- All underwent right leg magnetic resonance neurography.
- Funding: German Research Foundation.
- TC was positively correlated with tibial nerve conduction velocity (NCV; P=.02), peroneal NCV (P=.03), and tibial nerve compound muscle action potential (CMAP; P=.01).
- LDL-C was also positively correlated with each of these (P=.04, .02, and .001, respectively), but high-density lipoprotein cholesterol (HDL-C) was not.
- Increase in T2wFS-hypointense lipid equivalent lesion (LEL) load was negatively associated with NCVs of tibial (P=.01) and peroneal nerves (P<.001 and with cmaps of tibial peroneal nerves>
- Negative correlations between LEL load and:
- TC (P<.001>
- HDL-C (P=.006), and
- LDL-C (P=.003).
- neuropathy disability score (P=.005),
- neuropathy symptom score (P=.03),
- mean tibial nerve cross-sectional area (P<.001 and>
- mean maximum lesion length (P<.001>
- Cross-sectional data.
- Small sample size.