Takeaway
- Coenzyme Q10 (CoQ10) supplementation was not beneficial for patients with statin-associated myalgia or improved adherence to statin therapy.
Why this matters
- Statin associated muscle symptoms are common and affect adherence to statin treatment.
Study design
- A meta-analysis of 7 randomised controlled trials (n=321) compared the effects of CoQ10 supplementation (n=165) vs placebo (n=156) in patients with statin-associated myalgia.
- Funding: None disclosed.
Key results
- CoQ10 supplementation vs placebo was not associated with any significant improvement in myalgia symptoms (weighted mean difference, −0.42; 95% CI, −1.47 to 0.62; I2=84.6%).
- CoQ10 did not increase the proportion of patients remaining on the statin treatment vs placebo (relative risk, 0.99; 95% CI, 0.81-1.20).
Limitations
- Heterogeneity among studies.
- Small sample size.
References
References