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Clinical Summary

Does coenzyme Q10 supplementation improve statin-associated myalgia?

Takeaway

  • Coenzyme Q10 (CoQ10) supplementation was not beneficial for patients with statin-associated myalgia or improved adherence to statin therapy.

Why this matters

  • Statin associated muscle symptoms are common and affect adherence to statin treatment.

Study design

  • A meta-analysis of 7 randomised controlled trials (n=321) compared the effects of CoQ10 supplementation (n=165) vs placebo (n=156) in patients with statin-associated myalgia.
  • Funding: None disclosed.

Key results

  • CoQ10 supplementation vs placebo was not associated with any significant improvement in myalgia symptoms (weighted mean difference, −0.42; 95% CI, −1.47 to 0.62; I2=84.6%).
  • CoQ10 did not increase the proportion of patients remaining on the statin treatment vs placebo (relative risk, 0.99; 95% CI, 0.81-1.20).

Limitations

  • Heterogeneity among studies.
  • Small sample size.

References


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