Does high protein diet influence kidney function in patients with pre-diabetes?

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  • This study provides no evidence of decrease in kidney functions as a result of high protein intake after 1 year of intervention in older adults with pre-diabetes.
  • No association was found between adults with the lowest and the highest baseline protein intake and creatinine clearance, estimated glomerular filtration rate (eGFR), or serum creatinine.

Why this matters

  • Little is known about the effect of a higher protein intake on the change in kidney function in pre-diabetic overweight or obese individuals.

Study design

  • This sub-study of a randomised controlled trial assessed 310 participants with pre-diabetes and obesity/overweight.
  • Funding: Danish Agriculture & Food Council and others.

Key results

  • Highest protein consumption was 1.6 g/kg body weight/day vs 1.0 g/kg body weight/day among participants with the lowest intake (P<.0001).
  • Change in protein intake was found to be significantly associated with changes in creatinine clearance, urinary urea/creatinine ratio and serum urea (P<.0001 for all).
  • After adjustments, change in eGFR was positively associated with protein intake, and change in serum creatinine was inversely associated with change in protein intake (P<.05).
  • Change in creatinine clearance showed positive association with change in urea excretion (P<.0001).


  • Completeness of urine collection process was not assessed.