- This study provides no evidence of decrease in kidney functions as a result of high protein intake after 1 year of intervention in older adults with pre-diabetes.
- No association was found between adults with the lowest and the highest baseline protein intake and creatinine clearance, estimated glomerular filtration rate (eGFR), or serum creatinine.
Why this matters
- Little is known about the effect of a higher protein intake on the change in kidney function in pre-diabetic overweight or obese individuals.
- This sub-study of a randomised controlled trial assessed 310 participants with pre-diabetes and obesity/overweight.
- Funding: Danish Agriculture & Food Council and others.
- Highest protein consumption was 1.6 g/kg body weight/day vs 1.0 g/kg body weight/day among participants with the lowest intake (P<.0001).
- Change in protein intake was found to be significantly associated with changes in creatinine clearance, urinary urea/creatinine ratio and serum urea (P<.0001 for all).
- After adjustments, change in eGFR was positively associated with protein intake, and change in serum creatinine was inversely associated with change in protein intake (P<.05).
- Change in creatinine clearance showed positive association with change in urea excretion (P<.0001).
- Completeness of urine collection process was not assessed.