Does vitamin D status influence serum lipid profile during pregnancy?
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After adjustment for confounders, women with inadequate plasma 25(OH)D concentrations (<75 nmol/L) had significantly higher increase in the concentration of low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and TC/high-density lipoprotein cholesterol (HDL-C) ratios throughout pregnancy.
Why this matters
Increasing evidence shows that an abnormal lipid profile during gestation may increase the risk of cardiovascular disease.
This prospective study involving 194 pregnant women (mean age 26.7 y) evaluated the association between the first trimester 25(OH)D status and changes in serum lipid concentrations throughout pregnancy.
Funding: Research Foundation of the State of Rio de Janeiro.
69% of women had inadequate concentrations of 25(OH)D at baseline.
At baseline, women with 25(OH)D inadequacy had higher mean LDL-C than those with adequate concentrations in the first trimester (91.3 vs. 97.5 mg/dL; P=.064).