Does vitamin D status influence serum lipid profile during pregnancy?

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  • After adjustment for confounders, women with inadequate plasma 25(OH)D concentrations (<75 nmol/L) had significantly higher increase in the concentration of low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and TC/high-density lipoprotein cholesterol (HDL-C) ratios throughout pregnancy.

Why this matters 

  • Increasing evidence shows that an abnormal lipid profile during gestation may increase the risk of cardiovascular disease.

Study design

  • This prospective study involving 194 pregnant women (mean age 26.7 y) evaluated the association between the first trimester 25(OH)D status and changes in serum lipid concentrations throughout pregnancy.
  • Funding: Research Foundation of the State of Rio de Janeiro.

Key results

  • 69% of women had inadequate concentrations of 25(OH)D at baseline.
  • At baseline, women with 25(OH)D inadequacy had higher mean LDL-C than those with adequate concentrations in the first trimester (91.3 vs. 97.5 mg/dL; P=.064).
  • Independent of 25(OH)D concentrations, TC, HDL-C, LDL-C, TG, TG/HDL-C ratios, and TC/HDL-C ratios, increased throughout pregnancy (P<.001).
  • After adjusting for confounders, a direct and significant association was observed between baseline 25(OH)D status and changes in TC (β = 9.53; P=.026) and LDL-c (β = 9.99; P=.002) concentrations.


  • Information on individual's sun exposure was not collected.