Ductal carcinoma in situ: radiotherapy receipt not tied to demographic or lifestyle characteristics

  • Mullooly M & al.
  • Breast Cancer Res Treat
  • 17 Oct 2019

  • curated by Miriam Davis, PhD
  • Univadis Clinical Summaries
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Takeaway

  • Demographic and lifestyle characteristics, including cigarette smoking, are not associated with receipt of radiotherapy by patients with ductal carcinoma in situ (DCIS), according to the NIH-AARP Diet and Health Study.

Why this matters

Study design

  • Prospective cohort (n=1628) of incident DCIS (1995-2011) patients in the NIH-AARP Diet and Health Study.
  • Clinical information and radiotherapy were obtained from state cancer registries.
  • Funding: NIH.

Key results

  • Radiotherapy was received by 45% of DCIS patients (n=730).
  • Most lifestyle/demographic factors were not associated with radiotherapy receipt, including current smoking (OR, 0.97; 95% CI, 0.70-1.34).
    • Moderate alcohol consumption and infrequent physical activity were related to radiotherapy receipt but there were no significant trends for each (Ptrend=.18 and .35, respectively).
  • Radiotherapy receipt was strongly associated with several clinical factors:
    • More recent diagnosis (2005-2011 vs 1995-1999: OR, 1.60; 95% CI, 1.14-2.25).
    • Poorly vs well-differentiated tumors (OR, 1.69; 95% CI, 1.16-2.46).
    • Receipt of endocrine therapy vs no endocrine therapy (OR, 3.37; 95% CI, 2.56-4.44).

Limitations

  • Low response rate.
  • Observational design.