E-cigarettes more effective than nicotine replacement therapies

  • Hajek P & al.
  • N Engl J Med
  • 30 Jan 2019

  • curated by Dawn O'Shea
  • UK Medical News
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

E-cigarettes are almost twice as effective as nicotine replacement treatments (NRTs) in smoking cessation, according to a clinical trial led by Queen Mary University of London.

The multicentre trial randomly assigned 886 adults attending NHS stop-smoking services to either nicotine-replacement therapy (NRT) products of their choice, including product combinations, provided for up to 3 months, or an e-cigarette starter pack, with a recommendation to purchase further e-liquids of their choice. Treatment included weekly behavioural support for at least 4 weeks.

The 1-year abstinence rate was 18.0% in the e-cigarette group, as compared with 9.9% in the NRT group (relative risk [RR], 1.83; 95% CI, 1.30-2.58; P<.001 among participants who were abstinent at those in the e-cigarette group more likely than nrt to use their assigned product weeks.>

The authors say the findings are particularly noteworthy given that NRT was used under expert guidance, with access to the full range of products and with 88.1% of participants using combination treatments.

Overall, throat or mouth irritation was reported more frequently in the e-cigarette group, and nausea was more frequent in the NRT group. Compared to those on NRT, the e-cigarette group reported greater declines in the incidence of cough (RR, 0.8; 95% CI, 0.6-0.9) and phlegm production (RR, 0.7; 95% CI, 0.6-0.9) from baseline to 52 weeks. There were no significant between-group differences in the incidence of wheezing or shortness of breath.

Please confirm your acceptance

To gain full access to GPnotebook please confirm:

By submitting here you confirm that you have accepted Terms of Use and Privacy Policy of GPnotebook.