Early NSCLC: segmentectomy yields low recurrence rate at 5 years

  • Clin Lung Cancer

  • curated by Kelli Whitlock Burton
  • Univadis Clinical Summaries
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Takeaway

  • Patients with clinical stage 0 or IA NSCLC who underwent intentional segmentectomy had good recurrence-free survival (RFS) and OS, with low recurrence rates.
  • Time to recurrence (TTR) and RFS were worse in patients with a higher consolidation to maximum tumor diameter (C/T) ratio after intentional segmentectomy.

Why this matters

  • The use of segmentectomy in patients with early-stage lung cancer is expected to increase as a result of greater tumor detection with advanced screening technology, but the risk for recurrence after the procedure is unclear.

Study design

  • 166 patients with stage 0 or IA NSCLC underwent intentional segmentectomy.
  • Median follow-up, 48.8 months.
  • Funding: None.

Key results

  • 3.6% of patients experienced recurrence, and median TTR was 14.3 months.
  • 5-year RFS was 93.1% (95% CI, 87.9%-96.1%), and 5-year OS was 93.5% (95% CI, 87.7%-96.4%).
  • C/T ratio was significantly associated with TTR after intentional segmentectomy (HR, 1.1; P=.02).
  • Optimal cutoff value of the C/T ratio using the Youden index was 86.0% (sensitivity, 100%; specificity, 68.8%).
  • Patients with a C/T ratio ≤85.0% had significantly better 5-year TTR (100% vs 90.6%; P<.001 and rfs vs p=".02)" compared with those c ratio but there was no difference in os.>

Limitations

  • Retrospective, single-center study.