Early-onset CRC has distinct clinical, molecular features

  • Willauer AN & al.
  • Cancer
  • 11 Mar 2019

  • curated by Jim Kling
  • Univadis Clinical Summaries
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Takeaway

  • Early-onset colorectal cancer (CRC) has distinct clinical and molecular features, with unique subsets among patients aged

Why this matters

  • CRC incidence is on the rise in younger individuals, often with no identifiable predisposing genetic conditions.

Study design

  • Retrospective analysis of more than 36,000 patients from 4 cohorts.
  • Funding: NIH; MD Anderson.

Key results

  • Compared with patients aged ≥50 years, patients aged .
  • Patients aged 18-29 vs 30-49 years had lower odds of adenomatous polyposis coli mutations (OR, 0.56; P=.015), but greater odds of signet ring histology (OR, 4.89; P<.0001>).
  • Consensus molecular subtype 1 (CMS1) was most common in those aged .
  • Compared with early-onset patients with no complications, early-onset patients with IBD had greater risk for mucinous or signet ring histology (OR, 5.54; P=.0004) and reduced odds of APC mutations (OR, 0.24; P=.019).

Limitations

  • Retrospective analysis.