- Early-onset colorectal cancer (CRC) has distinct clinical and molecular features, with unique subsets among patients aged
Why this matters
- CRC incidence is on the rise in younger individuals, often with no identifiable predisposing genetic conditions.
- Retrospective analysis of more than 36,000 patients from 4 cohorts.
- Funding: NIH; MD Anderson.
- Compared with patients aged ≥50 years, patients aged .
- Patients aged 18-29 vs 30-49 years had lower odds of adenomatous polyposis coli mutations (OR, 0.56; P=.015), but greater odds of signet ring histology (OR, 4.89; P<.0001>).
- Consensus molecular subtype 1 (CMS1) was most common in those aged .
- Compared with early-onset patients with no complications, early-onset patients with IBD had greater risk for mucinous or signet ring histology (OR, 5.54; P=.0004) and reduced odds of APC mutations (OR, 0.24; P=.019).
- Retrospective analysis.