- Early poststroke depression (PSD) may negatively influence both short-term and long-term mortality in stroke survivors.
- Although the underlying mechanism remain unknown.
Why this matters
- Early PSD often remain underdiagnosed and untreated because of lack of gold standard for PSD assessment and diagnostic issues related to clinical characteristics of patients with stroke.
- Meta-analysis of 7 studies, involving 119,075 participants (with PSD, n=17,609; without PSD, n=101,466) identified after search across electronic databases.
- Funding: None disclosed.
- Random-effects meta-analysis showed higher rates of mortality in patients with PSD vs those without PSD (relative risk [RR], 1.50; P<.001>
- Subgroup analysis showed that risk for short-term mortality (1 or 2 years; RR, 1.70; P<.001 vs long-term mortality years rr p=".01)" was slightly higher in patients with psd.>
- According to meta-regression analyses, the estimate was influenced by sample proportion of men (P=.043).
- Treatment related-factors were not controlled.
- Lack of gold standard for poststroke depression diagnosis.