Early poststroke depression and mortality: what’s the association?

  • Bartoli F & al.
  • Front Psychiatry
  • 1 Jan 2018

  • curated by Sarfaroj Khan
  • UK Clinical Digest
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Takeaway

  • Early poststroke depression (PSD) may negatively influence both short-term and long-term mortality in stroke survivors.
  • Although the underlying mechanism remain unknown.

Why this matters

  • Early PSD often remain underdiagnosed and untreated because of lack of gold standard for PSD assessment and diagnostic issues related to clinical characteristics of patients with stroke.

Study design

  • Meta-analysis of 7 studies, involving 119,075 participants (with PSD, n=17,609; without PSD, n=101,466) identified after search across electronic databases.
  • Funding: None disclosed.

Key results

  • Random-effects meta-analysis showed higher rates of mortality in patients with PSD vs those without PSD (relative risk [RR], 1.50; P<.001>
  • Subgroup analysis showed that risk for short-term mortality (1 or 2 years; RR, 1.70; P<.001 vs long-term mortality years rr p=".01)" was slightly higher in patients with psd.>
  • According to meta-regression analyses, the estimate was influenced by sample proportion of men (P=.043).

Limitations

  • Treatment related-factors were not controlled.
  • Lack of gold standard for poststroke depression diagnosis.

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