EAU 2019: androgen deprivation therapy may trigger depression in men with prostate cancer


  • Mary Corcoran
  • Univadis Medical News
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Men who have undergone radical prostatectomy and later receive treatment with androgen deprivation therapy (ADT) may need preventive measures to reduce their risk of depression, according to a new study presented at the European Association of Urology congress

The study included 5,570 men from the Danish Prostate Cancer Registry who underwent radical prostatectomy, of which 773 were treated for depression after surgery. 

Compared with men not undergoing subsequent therapies, the authors found ADT increased the risk of depression (hazard ratio [HR] 1.8; 95% CI 1.4-2.3; P<.001 whereas salvage radiation without adt not significantly increase the risk of depression ci p=".07)." effect two treatments was additive with no sign interaction>

"This is a large study which shows that prostate cancer treatment can spill over to cause other issues. We need to be aware of this potential,” said EAU Adjunct Secretary General for Education, Prof Hendrik Van Poppel. “This argues for a multi-disciplinary approach to treating prostate cancer and underlines the value of following evidence-based guidelines to try to ensure that the patient receives comprehensive care," Prof Hendrik Van Poppel added. 

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