- In a real-world cohort, usage of adjuvant radiotherapy (ART) was high, despite lack of OS benefit, in women ≥70 years of age with T1, estrogen receptor positive (ER+) tumors who had undergone breast-conserving surgery (BCS).
- Neither having risk factors for local recurrence nor the estimated risk of death in 10 years was related to receipt of ART.
Why this matters
- Findings suggest that this patient population is overtreated with ART.
- Real-world database cohort (n=323) of women ≥70 years with ER+ T1 early breast cancer (eBCa) at Memorial Sloan Kettering Cancer Center (2010-2012).
- Funding: NIH.
- 53.8% of cohort received ART.
- RT usage decreased at older ages, with those receiving ART being younger than those who did not (74 vs 78 years; P<.0001>
- Median age of cohort: 75 years; median tumor size, 1 cm; all clinically node-negative.
- These factors were not associated with ART usage:
- estimated risk of death in 10 years;
- having comorbidities; and
- risk factors for local recurrence.
- ART usage (vs no usage) did not significantly influence OS (92% vs 85%; P=.051).
- Single-center, nonrandomized design.