ECE 2019: is vitamin D beneficial in polycystic ovarian syndrome?


  • Mary Corcoran
  • Univadis Medical News
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New research suggests daily vitamin D supplementation may be beneficial for women with polycystic ovarian syndrome (PCOS). 

As part of a new study, researchers assessed the impact of vitamin D supplementation on insulin resistance (IR) using homeostatic model assessment (HOMA) calculation in 60 people with PCOS and normal vitamin D levels. 

Participants were divided into four treatment groups: low glycaemic diet (LGD - 1,800 Kcal) plus metformin (MD); metformin plus LGD plus vitamin D supplementation 14,000 IU/weekly (MDW); metformin plus LGD plus vitamin D supplementation 2,000 IU/daily (MDD2); and metformin plus LGD plus vitamin D supplementation 4,000 IU/daily (MDD4).

After six months of treatment, the authors evaluated fasting glucose, fasting insulin and HOMA IR.

The study found daily supplementation with vitamin D showed some benefits. HOMA IR was reduced for 21 per cent in the MD group, 19 per cent in the MDW group, 24 per cent in the MDD2 group and 34 per cent in the MDD4 group (P<.05>. Furthermore, the number of biochemically confirmed ovulations during the six months of treatment was highest in the MDD4 group (2.45 ovulations per patients) compared with 1.61 in the MDD2 group, 1.14 in the MD group and 1.11 in the MDW group. 

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