Elevated lipoprotein(a), hypertension and renal insufficiency found to be independent risk factors for CAD in patients with familial hypercholesterolemia
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Elevated lipoprotein(a) [Lp(a)], hypertension and renal insufficiency are independent risk factors that predict CAD in patients with familial hypercholesterolemia (FH) beyond elevated pretreatment LDL-cholesterol; despite the cross-sectional design, this study proposes a need for identifying and managing these factors to reduce excess CAD risk in FH patients.
This cross-sectional study compared clinical and biochemical parameters in 390 patients with genetically confirmed FH with and without CAD.
Compared to FH patients without CAD, those with CAD were older and more often male, and had a higher prevalence of hypertension, smoking, diabetes, obesity, reduced eGFR, ...