- In women with endometrial cancer, use of indocyanine green dye instead results in a 26.5% increase in sentinel lymph node (SLN) detection rates per hemipelvis vs methylene blue dye.
Why this matters
- Indocyanine green may become the new standard in SLN mapping.
- Parallel, randomized controlled superiority trial of 132 patients who underwent SLN mapping after the injection of blue dye on one side of the cervix and ICG on the other side.
- 67 patients were randomly assigned to blue dye on the left (green dye on the right) and 65 patients to blue dye on the right (green dye on the left).
- Funding: None disclosed.
- Detection of ≥1 SLN was higher on the side injected with green dye vs blue dye (90.9% vs 64.4%; P<.0001 style="list-style-type:circle;">
- Similar SLN detection rates were observed whether the surgical approach was robotic (89.1% vs 65.2%) or laparoscopic (91.9% vs 63.9%).
- Sensitivity, negative predictive value were not evaluated.