Endometrial cancer: minimally invasive surgery shows QoL benefit

  • Ferguson SE & et al.
  • Gynecol Oncol
  • 20 Apr 2018

  • curated by Deepa Koli
  • Univadis Clinical Summaries
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Takeaway

  • In patients with endometrial cancer, minimally invasive surgery (MIS) improves QoL beyond early postoperative period vs laparotomy.
  • Patient-reported outcomes (PROs) were similar with laparoscopy and robotic-assisted surgeries.

Why this matters

  • Studies have reported comparable survival outcomes from MIS and laparotomy, but data on overall health-related QoL and sexual health are unclear.

Study design

  • Prospective cohort study of 468 patients with endometrial cancer who underwent laparotomy or MIS (laparoscopic or robot-assisted).
  • Funding: Princess Margaret Cancer Foundation.

Key results

  • No significant differences in the Functional Assessment of Cancer Therapy (FACT-G), Brief Pain Inventory (BPI), Euro QoL 5-Dimensions (EQ-5D), or sexual health scores between the laparoscopic and robotic groups at baseline or any time postsurgery (P>.05).
  • MIS and laparotomy groups had significant differences in means for each PRO:
    • 3-month FACT-G (82.3 vs 77.9; P=.035),
    • 3-week FACT-EN (124.5 vs 112.1; P<.0001>
    • 3-month EQ-5D (0.88 vs 0.84; P=.0495), and
    • 3-week mean BPI interference pain scores (2.0 vs 3.0; P=.0008).
  • MIS vs laparotomy significantly improved:
    • Physical well-being scores at week 3 (mean, 20.9 vs 17.7; P<.0001>
    • Functional well-being scores at 6 months (mean, 21.4 vs 19.4; P=.0184).
  • Sexual health scores did not change significantly over time in either group.

Limitations

  • Observational study.

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