- In patients with endometrial cancer, minimally invasive surgery (MIS) improves QoL beyond early postoperative period vs laparotomy.
- Patient-reported outcomes (PROs) were similar with laparoscopy and robotic-assisted surgeries.
Why this matters
- Studies have reported comparable survival outcomes from MIS and laparotomy, but data on overall health-related QoL and sexual health are unclear.
- Prospective cohort study of 468 patients with endometrial cancer who underwent laparotomy or MIS (laparoscopic or robot-assisted).
- Funding: Princess Margaret Cancer Foundation.
- No significant differences in the Functional Assessment of Cancer Therapy (FACT-G), Brief Pain Inventory (BPI), Euro QoL 5-Dimensions (EQ-5D), or sexual health scores between the laparoscopic and robotic groups at baseline or any time postsurgery (P>.05).
- MIS and laparotomy groups had significant differences in means for each PRO:
- 3-month FACT-G (82.3 vs 77.9; P=.035),
- 3-week FACT-EN (124.5 vs 112.1; P<.0001>
- 3-month EQ-5D (0.88 vs 0.84; P=.0495), and
- 3-week mean BPI interference pain scores (2.0 vs 3.0; P=.0008).
- Physical well-being scores at week 3 (mean, 20.9 vs 17.7; P<.0001>
- Functional well-being scores at 6 months (mean, 21.4 vs 19.4; P=.0184).
- Observational study.