- Endometriosis is associated with reduced levels of anti-Müllerian hormone (AMH) and increased levels of follicle-stimulating hormone (FSH), both indicative of reduced ovarian reserve, in women with infertility.
Why this matters
- The relationship between endometriosis and ovarian reserve is poorly understood.
- Women with endometriosis had lower mean AMH levels (2.5 ng/mL for women with prior ovarian surgery, 2.5 ng/mL for women without prior ovarian surgery) than women with male factor infertility (reference group, 3.6 ng/mL; β, −1.21; 95% CI, −1.79 to −0.62 and β, −1.11; 95% CI, −1.68 to −0.54, respectively).
- Women with endometriosis had higher mean FSH levels (8.6 IU/L for women with prior ovarian surgery, 8.4 IU/L for women without prior ovarian surgery) than women with male factor infertility (7.3 IU/L; β, 1.37; 95% CI, 0.39-2.34 and β, 0.96; 95% CI, 0.04-1.87, respectively).
- 671 women seeking fertility treatment, 78 with endometriosis and prior ovarian surgery, 60 with endometriosis but no prior ovarian surgery, and 533 with male factor infertility, were included.
- Funding: None disclosed.
- Retrospective study design.