Endometriosis tied to depleted ovarian reserve in women with infertility

  • Romanski PA & al.
  • J Assist Reprod Genet
  • 16 Apr 2019

  • International Clinical Digest
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Takeaway

  • Endometriosis is associated with reduced levels of anti-Müllerian hormone (AMH) and increased levels of follicle-stimulating hormone (FSH), both indicative of reduced ovarian reserve, in women with infertility.

Why this matters

  • The relationship between endometriosis and ovarian reserve is poorly understood.

Key results

  • Women with endometriosis had lower mean AMH levels (2.5 ng/mL for women with prior ovarian surgery, 2.5 ng/mL for women without prior ovarian surgery) than women with male factor infertility (reference group, 3.6 ng/mL; β, −1.21; 95% CI, −1.79 to −0.62 and β, −1.11; 95% CI, −1.68 to −0.54, respectively).
  • Women with endometriosis had higher mean FSH levels (8.6 IU/L for women with prior ovarian surgery, 8.4 IU/L for women without prior ovarian surgery) than women with male factor infertility (7.3 IU/L; β, 1.37; 95% CI, 0.39-2.34 and β, 0.96; 95% CI, 0.04-1.87, respectively).

Study design

  • 671 women seeking fertility treatment, 78 with endometriosis and prior ovarian surgery, 60 with endometriosis but no prior ovarian surgery, and 533 with male factor infertility, were included.
  • Funding: None disclosed.

Limitations

  • Retrospective study design.

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