- Influenza vaccination is linked to an 18% reduced risk for death among people with hypertension.
Why this matters
- Influenza has been implicated as a trigger in myocardial infarction (MI) and stroke.
- People with hypertension are at increased risk for cardiovascular (CV) death, especially from MI and stroke, said study author Tor Biering-Sørensen of Gentofte University Hospital in Copenhagen, in presenting the results.
- The potential for an influenza vaccine to affect these risks has not previously been investigated, said Biering-Sørensen, and neither US nor European hypertension guidelines mention it.
- Biering-Sørensen summed up the key message of the study: “Physicians should encourage the flu vaccine in patients with hypertension.”
- In any given influenza season, influenza vaccination was linked to:
- 18% relative risk reduction for all-cause mortality (HR, 0.82; P<.001>
- 16% reduction for CV death (HR, 0.84; P<.001 and>
- 10% relative risk reduction for MI/stroke-related mortality (HR, 0.90; P<.017>
- Danish registry data for 608,452 patients, ages 18-100 years, with hypertension, on at least 2 classes of antihypertensives, with no CV- or cancer-related comorbidities, covering influenza seasons during 2007-2016.
- Funding: Herlev & Gentofte University Hospital Internal Research Fund; Novo Nordisk Foundation.
- Presented at a conference without peer review.