ESC 2019 — Recommend influenza vaccine for patients with hypertension


  • Emily Willingham, PhD
  • Conference Reports
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Takeaway

  • Influenza vaccination is linked to an 18% reduced risk for death among people with hypertension. 

Why this matters

  • Influenza has been implicated as a trigger in myocardial infarction (MI) and stroke.
  • People with hypertension are at increased risk for cardiovascular (CV) death, especially from MI and stroke, said study author Tor Biering-Sørensen of Gentofte University Hospital in Copenhagen, in presenting the results.
  • The potential for an influenza vaccine to affect these risks has not previously been investigated, said Biering-Sørensen, and neither US nor European hypertension guidelines mention it. 
  • Biering-Sørensen summed up the key message of the study: “Physicians should encourage the flu vaccine in patients with hypertension.” 

Results

  • In any given influenza season, influenza vaccination was linked to:
    • 18% relative risk reduction for all-cause mortality (HR, 0.82; P<.001>
    • 16% reduction for CV death (HR, 0.84; P<.001 and>
    • 10% relative risk reduction for MI/stroke-related mortality (HR, 0.90; P<.017>

Study design

  • Danish registry data for 608,452 patients, ages 18-100 years, with hypertension, on at least 2 classes of antihypertensives, with no CV- or cancer-related comorbidities, covering influenza seasons during 2007-2016.
  • Funding: Herlev & Gentofte University Hospital Internal Research Fund; Novo Nordisk Foundation.

Limitations

  • Presented at a conference without peer review.

 

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