ESMO 2018 – One in six premenopausal breast cancer patients inadequately adherent to tamoxifen after one year


  • Jo Whelan
  • Oncology Conference reports
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • One in six premenopausal women (16%) showed inadequate adherence to tamoxifen after one year.
  • 10.7% had undetectable serum levels, indicating complete nonadherence.
  • Self-declaration is not a reliable indicator of adherence.
  • Doctors should ask about side effects, encourage openness about nonadherence, and work with patients on strategies to help them adhere.

Why this matters

Nonadherence to long-term hormonal therapy (ie, taking

Key results

  • 16.0% (188/1177) of premenopausal women prescribed tamoxifen in the CANTO trial showed inadequate adherence at one year (based on serum assessment of tamoxifen
  • Within this group, 10.7% of the total population under study had undetectable levels of tamoxifen and were classed as nonadherent.
  • Half of those with inadequate adherence had self-declared as adherent.

Study design

  • CANTO COMPLETE was a pre-defined substudy of CANTO, a French prospective longitudinal study of 12,000 patients with recently diagnosed stage I-III breast cancer. The objective of CANTO is to characterize the long-term impact of treatment toxicities.
  • CANTO COMPLETE examined the prevalence and predictors of nonadherence to hormone therapy in premenopausal women, using serum assessment of drug levels and matching them with patients’ self-declaration of adherence.

Limitations

Serum tamoxifen was measured at only one time point, reflecting levels over the previous month only.

Comment

“Non-compliance with adjuvant hormonal treatment is an under-appreciated and under-reported problem and places patients at risk of inadequate clinical benefit,” said ESMO’s invited commentator, Giuseppe Curigliano, University of Milan, Italy.

Please confirm your acceptance

To gain full access to GPnotebook please confirm:

By submitting here you confirm that you have accepted Terms of Use and Privacy Policy of GPnotebook.

Submit