Esophageal cancer: MIE yields better survival in meta-analysis

  • Gottlieb-Vedi E & al.
  • Ann Surg
  • 21 Feb 2019

  • curated by Jim Kling
  • Univadis Clinical Summaries
Access to the full content of this site is available only to registered healthcare professionals. Access to the full content of this site is available only to registered healthcare professionals.

Takeaway

  • Minimally invasive esophagectomy (MIE) was associated with a lower 5-year mortality than open esophagectomy (OE) in patients with esophageal cancer.

Why this matters

  • Previous studies compared long-term survival between MIE and OE and found no difference in survival, but they had limited sample sizes.

Study design

  • Meta-analysis of 55 studies (53 cohort studies, 2 randomized clinical trials).
  • Funding: Swedish Research Council and Swedish Cancer Society.

Key results

  • A pooled analysis of 34 studies that included all-cause 5-year mortality revealed a lower mortality with MIE (HR, 0.82; 95% CI, 0.76-0.88).
  • A pooled analysis of 53 studies that included all-cause 3-year mortality showed a lower mortality associated with MIE (HR, 0.85; 95% CI, 0.80-0.92).
  • A pooled analysis of 13 studies reporting disease-specific 5-year mortality showed lower mortality associated with MIE (HR, 0.83; 95% CI, 0.75-0.91).
  • A pooled analysis of 22 studies reporting disease-specific 3-year mortality showed lower mortality associated with MIE (HR, 0.84; 95% CI, 0.77-0.92).

Limitations

  • Most included studies were retrospective.

Please confirm your acceptance

To gain full access to GPnotebook please confirm:

By submitting here you confirm that you have accepted Terms of Use and Privacy Policy of GPnotebook.

Submit