- Minimally invasive esophagectomy (MIE) was associated with a lower 5-year mortality than open esophagectomy (OE) in patients with esophageal cancer.
Why this matters
- Previous studies compared long-term survival between MIE and OE and found no difference in survival, but they had limited sample sizes.
- Meta-analysis of 55 studies (53 cohort studies, 2 randomized clinical trials).
- Funding: Swedish Research Council and Swedish Cancer Society.
- A pooled analysis of 34 studies that included all-cause 5-year mortality revealed a lower mortality with MIE (HR, 0.82; 95% CI, 0.76-0.88).
- A pooled analysis of 53 studies that included all-cause 3-year mortality showed a lower mortality associated with MIE (HR, 0.85; 95% CI, 0.80-0.92).
- A pooled analysis of 13 studies reporting disease-specific 5-year mortality showed lower mortality associated with MIE (HR, 0.83; 95% CI, 0.75-0.91).
- A pooled analysis of 22 studies reporting disease-specific 3-year mortality showed lower mortality associated with MIE (HR, 0.84; 95% CI, 0.77-0.92).
- Most included studies were retrospective.