- 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) reliably detects esophageal carcinoma recurrence even in the absence of clinical indications.
Why this matters
- About half of esophageal cancers recur within 2 years after surgery with curative intent.
- FDG PET/CT has been shown to be useful in studies in which recurrence was suspected.
- Retrospective analysis of 782 FDG PET/CT scans from 375 patients at a single institution.
- A PET/CT scan was determined to be negative if recurrence was not diagnosed within 6 months.
- Funding: Ministry of Health & Welfare, Korea.
- FDG PET/CT scan had a sensitivity of 100% and a specificity of 94.0%.
- The positive predictive value was 59.8%, with a positive likelihood ratio of 16.7.
- The negative predictive value was 100%, and the negative likelihood ratio was 0.
- When researchers conducted analyses by cancer stage, there was no significant difference of the sensitivity, specificity, or accuracy of FDG PET/CT between groups.
- FDG PET/CT had a higher PPV for stage II or stage III cancers than for stage I (67.1% vs 39.3%; P=.010).
- Retrospective, single-institution Korean population.